Underscoring the significance of these types of proteins, malfunctioning of different membrane proteins have been associated with diseases ranging from brain edema, to cancer, and neurodegenerative diseases. Our current targets include P-type ATPases aquaporins and ion channels of various kinds. The focus of our group is eukaryotic and prokaryotic membrane proteins that are linked to ion homeostasis and in particular transport of transition metals across cellular membranes. This lack of structural knowledge significantly impairs our understanding of the functions and mechanisms of these proteins, hereby preventing further applied, biomedical and biotechnological research. Compared to soluble proteins, however, an understanding at the molecular-level for the membrane bound counterparts lags far behind. Thus, combined with the GRS, this will be a great opportunity for early career researchers to present their work.Membrane proteins are of critical importance to nearly every aspect of cell physiology, comprising about one-third of all proteins. Many talks at the GRC will be selected from abstracts. It is also the first time the GRC will be accompanied by a GRS. This is first time the membrane protein folding GRC will be held in Europe, following 3 successful meetings in the US. Topics will additionally focus on new methods to prepare and probe samples of increasing complexity ranging from artificial, in vitro systems to more intricate cellular preparations. The role of lipids in folding, regulation and membrane organization will also be discussed. Sessions will address recent progress in developing and tailoring state-of-the-art measurement techniques and computational approaches to elucidate molecular mechanisms. The GRC will explore new tools that can be applied to the challenging problem of membrane protein folding, with an emphasis on connecting fundamental parameters obtained on model systems to cellular consequences.
#MEMBRANE PRO SERIES#
The latest meeting is the 4th in the series and cultivates the combination of cutting-edge biophysics, biochemistry and cell biology established in the initial conferences. This relatively new conference series brings together researchers tackling this frontier of membrane protein folding. The pivotal class of membrane proteins has been avoided as they are notoriously difficult to study. The majority of folding research has focused on a subset of the proteome experimentally-amenable, water-soluble proteins. Protein function is governed by the 3D fold, with health depending on the success of folding and disease on its failure. This conference showcases advances in the evolving field of membrane protein folding.Ĭorrectly folded proteins are essential for life.
#MEMBRANE PRO FREE#
In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The Membrane Protein Folding GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages.
Seed Funding for Gordon Research Seminars.Proposing a New Gordon Research Conference.Hong Kong University of Science and Technology.
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